Mounjaro® Results: Timeline & What to Expect
Key takeaways:
Research shows Mounjaro® can help people lose an average of 22.5 percent of their body weight in 72 weeks.
Mounjaro® results vary, though. How much weight you lose depends on your dose, starting weight, and the lifestyle changes you make.
You might gradually lose weight on Mounjaro® and see other results like better blood sugar control, blood pressure, and cholesterol levels.
Mounjaro® (tirzepatide) is licensed in the United Kingdom for type 2 diabetes and the treatment of obesity. It can help people with overweight and obesity lose weight. But what does that look like, exactly?
Mounjaro® results vary from person to person — that’s why you may see very different Mounjaro® before-and-after photos with people’s success stories. But you might lose about 22.5 percent of your body weight over 72 weeks, depending on your dose.
Keep reading for a rough Mounjaro® weight loss timeline of what to expect month on month, and find out which factors can impact how much weight you lose on the medicine.
Mounjaro® Results: Weight Loss Timeline
Mounjaro® results vary from person to person. However, you can expect to see some weight loss in your first month of taking the dual GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist medicine.
Here’s a rough guide to what your Mounjaro® weight loss journey could look like.
Mounjaro® Weight Loss Results
You may start noticing weight loss in your first month on Mounjaro®. Don’t fret if you don’t see weight loss straight away — that doesn’t mean the medicine isn’t working.
It can take time for Mounjaro® to build up in your system, start affecting your appetite, and promote weight loss.
Research on Mounjaro® Results for Weight Loss
A 2022 clinical trial found that people taking Mounjaro® and making lifestyle changes lost an average of about 4 percent of their body weight after a month. After two months, they’d lost about 6 percent of their body weight.
Weight loss continued month on month, and people on higher doses of Mounjaro® lost more weight.
By 72 weeks, people taking 15 mg (milligrams) of Mounjaro® lost an average of 22.5 percent of their body weight.
One thing to be aware of? Weight loss plateaus. A weight loss plateau is when weight loss progress slows down or stops. This can happen after around 24 to 36 weeks on Mounjaro®.
Increasing your dose — if you’re not on the highest dose already — and making lifestyle tweaks can help you kickstart weight loss again.
Weight loss your way
Mounjaro® Appetite Changes
You might start noticing appetite suppression in your first week on Mounjaro®. But, again, this might not kick in straight away.
In a 2025 study, participants experienced a reduced appetite and other changes to their hunger by the third week on Mounjaro®.
They felt:
Less hunger
More fullness (satiety)
Fewer cravings for sweet, salty, and fatty foods
Less inclination to stress eat
These changes may come on gradually and stick around as you continue taking the medicine.
Mounjaro® Side Effects
Mounjaro® side effects can crop up when you first start taking the medication and when your dose increases every four weeks.
Common side effects can include:
Nausea
Vomiting
Diarrhoea
Constipation
Stomach pain
These side effects should get better with time, so you may feel better month by month.
Mounjaro® Results Beyond Weight Loss
Beyond weight loss, you might notice other health benefits of taking Mounjaro®.
Health benefits can include:
Lower blood sugar levels
Reduced waist circumference
Improved blood pressure
Lower cholesterol levels
As you move towards a healthy weight, you’ll also reduce your risk of obesity-related health conditions, like stroke, heart disease, type 2 diabetes, and some types of cancer.
Plus, there are the benefits beyond health metrics — like more energy, better sleep, and a brighter mood. Mounjaro® success stories include women reporting more confidence and happiness.
How Much Weight Can You Lose on Mounjaro®?
Research from 2022 found that people taking 15 mg of Mounjaro® and making lifestyle changes lost an average of 22.5 percent of their body weight over 72 weeks. This was equivalent to 23.6 kilograms, or about 3.7 stone.
Of course, we all lose weight at different rates, and many factors impact how much — and how quickly — we lose weight.
Factors Affecting Mounjaro® Weight Loss Results
Many factors can affect your Mounjaro® results, including the dose you take, your starting body weight, how your body reacts to the medication, and the lifestyle changes you make.
Here’s a closer look.
Your Dose
Higher doses of Mounjaro® can lead to more weight loss over time.
After 72 weeks on Mounjaro®, participants in one study taking:
5 mg lost an average of 16 percent of their body weight
10 mg lost an average of 21.4 percent of their body weight
15 mg lost an average of 22.5 percent of their body weight
Your dose will gradually increase every four weeks until you reach a maintenance dose. Then, you’ll stay on that maintenance dose for the rest of your time on Mounjaro®.
Your GP (general practitioner) or prescribing clinician can guide you on when to increase your Mounjaro® dosage as part of your treatment plan.
How Your Body Reacts
Everyone reacts differently to medication. How quickly you see results depends on how quickly you feel the effects of Mounjaro® on your appetite and whether you experience side effects that mean you need to stay on a low dose.
Plus, we all lose weight at different speeds, and it doesn’t always happen at a nice, even rate. You might lose no weight one week and then more weight the next.
Health problems — like polycystic ovary syndrome (PCOS) and type 2 diabetes — can also make weight loss harder and affect your results.
The Lifestyle Changes You Make
A healthcare provider will probably prescribe Mounjaro® alongside eating more nutritious food and exercising more to promote weight loss. But the changes you make can influence how much weight you lose — and how quickly you lose it.
This includes your training routine and how much of a calorie deficit you’re in — when you consume fewer calories than your body burns.
Here’s how you can get the best results from Mounjaro®:
Eat a balanced diet with fruit, veg, lean protein, whole grains, and healthy fats.
Do more movement, including cardio, strength training, and increasing your general physical activity level throughout the day.
Get seven to nine hours of sleep a night.
Keep stress levels as low as you can.
Unlock your treatment plan
Mounjaro® Results: Final Thoughts
Mounjaro® results vary from one person to the next. But you could see significant weight loss that can improve your quality of life and many aspects of your health.
Here’s a recap:
Mounjaro® can lead to significant weight loss. In clinical trials, people on 15 mg of Mounjaro® lose an average of 22.5 percent of their body weight (or 3.7 stone) after 72 weeks.
Many factors impact Mounjaro® results. That includes your dose, how your body reacts to the medicine, and the lifestyle changes you make.
Let your GP or private clinician know if you don’t see any results. They may recommend increasing your dose (if you’re not on the highest dose), making lifestyle adjustments, or trying a different weight loss medication, such as Wegovy® (semaglutide).
Medicines like Mounjaro® can help you reach your weight loss goals and improve your health and well-being. You can learn more about your options through the Hers U.K. platform.
Your plan is waiting
FAQs
See answers to commonly asked questions about Mounjaro® results for weight loss.
What should I do if I don’t see Mounjaro® results?
If you don’t see Mounjaro® results, reach out to your GP or prescribing clinician. They may recommend increasing your dose — if you’re not on the highest dose yet — or making lifestyle adjustments. If you still don’t see any Mounjaro® results, they may suggest trying a different weight loss medicine.
Do you lose more weight on higher doses of Mounjaro®?
Yes, you lose more weight on higher doses of Mounjaro® than on lower doses. Research shows that people taking 5 mg of Mounjaro® see an average weight loss of 16 percent of their body weight over 72 weeks, whereas people taking 15 mg lose an average of 22.5 percent of their body weight.
What are Mounjaro® alternatives?
Mounjaro® alternatives include other weight loss injections like Wegovy®, Saxenda®, and Nevolat (a liraglutide alternative), as well as oral weight loss medications like orlistat (Xenical®, Orlos®) and Mysimba®. These weight loss treatments work in different ways. A GP or private healthcare provider can help you figure out the best medicine for you.
This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your GP about the risks and benefits of any treatment.